TETsuo SAwAI and TAKAsHI YosHIDA
نویسندگان
چکیده
The syllergistic elTect of aβ 一1actam anbiotic in combinatioll with aβ 一lactamase illhibitor (cloxaciHin)on Gram・negative bacteria producing various types of、e-lactamases was studied w1tll respect to the properties of the enzynles by usingaset of bacterial strains we had developed previously for evaluation of/3-1actamase stability orβ 一iactam antibiotics1). Cloxacillin showed strong synergy in conlbiIlatiQn with ampiclllin or cephalosporil、s against typical cephalosporinase-producing bacteria, but no1 against pellicillinase-Producing bacteria. Analysis of the results indicated that the efPcacy of a competitive inhibitor such as cloxacimll is grcatly inHuenced by the following factors:the affinity or the inhibitor for the enzyme, the diffrence between the amnity or thc inhibitor for the enzyme and that of the cQmbined antibiotic for the enzyme, and the ability of the i!lhibitor to pene〔rate the bacterial outer membrane. Itwas also demonstrated thauhis information concerning the emcacy of an inhibitor could easily be obtained by using the set of bacterial stra1ns and the nlethods dcscribed.
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